Article Summary: The Protective Effects of Nicotinamide Mononucleotide on UVB-Induced Skin Damage in Mice
Introduction
Ultraviolet light causes skin oxidation, inflammation, and diseases
Nicotinamide mononucleotide (NMN) has anti-oxidation effects and improves physiological processes
Study on NMN's Protective Effect
- Research explores the protective effect of NMN on UVB-induced photodamage
- NMN treatment blocks UVB-induced photodamage in mice
- NMN maintains normal skin structure, collagen fibers, and skin thickness
- NMN reduces production of inflammatory mast cells
- NMN maintains normal liver morphology after UVB exposure
Mechanisms of NMN's Effect
- NMN increases antioxidant ability and regulates proinflammatory response to UVB irradiation
- NMN activates AMPK signaling pathway and increases expression of downstream antioxidant genes
- NMN downregulates expression of inflammatory cytokines and inhibits activation of NFκB-p65
Experimental Design and Results
- NMN administered through intraperitoneal injection protects against UVB-induced skin damage
- Histomorphological techniques, biochemical analysis, and gene/protein expression analysis were used
- NMN improves liver and skin structure, oxidative stress indicators, and inflammatory markers
Conclusion and Future Research
NMN has a protective effect on UVB-induced skin damage in mice
NMN regulates oxidation and inflammation through signal pathways like NF-κB and AMPK
NMN administration could be further studied for its potential applications
Funding
Research was funded by various sources in China
Data Sharing and Ethics
- All data generated or analyzed during the study are included in the article
- Access to the datasets can be obtained from the corresponding author
- The study protocol was approved by the Ethics Committee, ensuring animal welfare
Conflicts of Interest
The authors declare no conflicts of interest
Note: The headings provided in this summary are not an exhaustive representation of all the information in the article, but rather a synthesis of the main points covered.
Title of paper: β-Nicotinamide Mononucleotide (NMN) Administrated by Intraperitoneal Injection Mediates Protection Against UVB-Induced Skin Damage in Mice
Author(s): Zhou X, Du HH, Long X, Pan Y, Hu J, Yu J, Zhao X.
Year published: 2021
Published in: J Inflamm Res
Original article can be found here.
