NMN Supplementation Shows Potential to Mitigate Aging-Related Muscle Disorders in Healthy Older Men
Introduction:
Aging is known to increase the risk of various diseases, such as diabetes, cardiovascular diseases, cancer, and neurological diseases. Studies have shown that decreased levels of a molecule called nicotinamide adenine dinucleotide (NAD+) are associated with aging and age-related diseases. Animal studies have demonstrated that supplementing with NAD+ precursors like nicotinamide mononucleotide (NMN) can increase NAD+ levels and improve health and lifespan. Limited human data on NMN supplementation are available, but research is suggesting its potential as an effective NAD+ booster for preventing aging-related muscle dysfunctions in humans.
Study Design and Findings:
A recent study investigated the effects of chronic oral supplementation of NMN on healthy older participants. The study included 42 men aged 65 years or older who were randomly assigned to receive either 250mg of NMN per day or a placebo for 12 weeks. The primary objective of the study was to evaluate the effects of NMN on blood NAD+ concentration and body composition.
The results showed that NMN supplementation at 250mg/day for 12 weeks was safe and well-tolerated with no serious adverse events. Participants who received NMN supplementation had increased levels of NAD+ and NAD+-related metabolites in their whole blood. Additionally, NMN supplementation was found to partly improve motor functions, such as gait speed and grip strength. However, it did not have a significant effect on other aging-related phenotypes, such as audibility, vascular function, or cognitive function. The study suggests that chronic NMN supplementation may improve muscle strength, but further investigation is needed to confirm these findings and determine its effectiveness in different populations.
Conclusion:
The study provides evidence that chronic oral supplementation of NMN at a dosage of 250mg per day is safe and well-tolerated in healthy older men. It increases NAD+ levels and shows potential in improving muscle performance, an important indicator of aging. Although previous studies on NMN administration in animals and humans have reported no significant side effects and positive outcomes, larger studies are needed to validate the results and explore the efficacy of NMN supplementation in different populations.
Supplementary Information:
The document includes supplementary information and supplemental materials in the form of PDF files that provide additional details and data related to the study. These files can be accessed and downloaded for further reference or in-depth understanding of the subject matter.
Title of paper: Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older men
Author(s): Igarashi M, Nakagawa-Nagahama Y, Miura M, Kashiwabara K, Yaku K, Sawada M, Sekine R, Fukamizu Y, Sato T, Sakurai T, Sato J, Ino K, Kubota N, Nakagawa T, Kadowaki T, Yamauchi T.
Year published: 2022
Published in: NPJ Aging
Original article can be found here.
