Side Effects of NMN (Nicotinamide Mononucleotide)

Side Effects of NMN (Nicotinamide Mononucleotide)

Nicotinamide Mononucleotide (NMN) has gained significant attention in the realm of health and wellness. As a precursor to NAD+, a coenzyme essential for cellular energy production, NMN has been linked to numerous health benefits, especially in the context of aging. However, like any supplement, it's essential to be aware of potential side effects. In this article, we'll delve into the side effects of NMN, backed by scientific research.

What is NMN?

NMN is a naturally occurring compound that plays a vital role in our cells' energy production. It's a direct precursor to Nicotinamide Adenine Dinucleotide (NAD+), a crucial coenzyme that declines with age. The decline in NAD+ levels has been associated with various age-related diseases, making NMN a sought-after supplement for its potential anti-aging benefits.

Potential Side Effects of NMN

While NMN is generally considered safe, some potential side effects have been noted:

  1. Sleep Disturbances: Some individuals have reported difficulty sleeping after taking NMN, especially when consumed in the evening. It's hypothesized that the increased cellular energy might lead to heightened alertness, making it challenging to fall asleep.

  2. Mild Nausea: A few users have experienced mild nausea after taking NMN, especially on an empty stomach. It's always recommended to follow dosage instructions and consider taking the supplement with food.

  3. Skin Flush: A warm, tingling sensation or redness on the skin, similar to a niacin flush, has been reported by some NMN users.

Research on NMN

Several studies have been conducted on NMN, shedding light on its effects:

  1. A study titled "Therapeutic effects of growth factor cocktail (CellcurinTM) containing FGF5s (fibroblast growth factor 5 short) and NMN (nicotinamide mononucleotide) in patients with androgenetic alopecia: A split study" explored the effects of NMN in combination with other compounds on hair regrowth. While the primary focus was on hair growth, the study did not report any significant side effects related to NMN.

  2. Another research titled "Nicotinamide Mononucleotide Administration Prevents Doxorubicin-Induced Cardiotoxicity and Loss in Physical Activity in Mice" investigated the protective effects of NMN against cardiotoxicity. The study found that NMN had protective effects on the heart without any reported side effects.

  3. A study on the "Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice" found that NMN had positive effects on neurovascular function in aged mice, with no significant side effects reported.


NMN, as a supplement, holds promise in the realm of health and anti-aging. While it's generally considered safe, it's essential to be aware of potential side effects and always consult with a healthcare professional before starting any new supplement. As with any supplement, individual experiences may vary, so it's crucial to listen to your body and adjust accordingly.

Discover the benefits of our NMN product here.

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