Promising Study Shows Oral NMN Administration Boosts NAD+ Levels in Humans, with No Adverse Effects
- Population aging linked to physiological declines and aging-related diseases is a global challenge.
- NAD+ is a molecule involved in energy metabolism and cellular functions, and its levels decline with age.
- NAD+ supplementation therapies, such as NMN, are being explored as potential interventions against aging.
Study Design and Objectives:
- Placebo-controlled, randomized, double-blind trial investigated the safety and efficacy of orally administered NMN in healthy subjects.
- Primary objective was to assess NMN safety, while secondary objectives focused on NAD+ levels and other metabolites.
Safety and Tolerability of NMN:
- NMN administration for 12 weeks caused no abnormalities in physiological and laboratory tests.
- No serious adverse effects were observed, with only minor gastrointestinal symptoms reported.
Increase in NAD+ Levels:
- NMN administration significantly increased NAD+ levels in whole blood.
- No significant changes were observed in NMN levels or other NAD metabolites.
- Pulse rate and ALT levels showed correlations with increased NAD+ levels after NMN administration.
- Oral NMN administration at a dose of 250 mg/day for 12 weeks was found to be safe and well-tolerated.
- NAD+ levels increased significantly, indicating a potential for NMN to boost NAD+ levels in humans.
- Further studies with larger sample sizes and exploration of tissue specificity are necessary.
- The consequences of increased NAD+ levels and its impact on metabolism and physiological activities need further investigation.
Implications and Future Research:
- NMN administration may have potential benefits in aging and aging-related diseases.
- Raw data supporting the study's conclusions will be made available to promote scientific reproducibility.
- Ethical considerations and informed consent were obtained from all study participants.
- The study received funding from several sources and the authors declare no conflicts of interest.
- The researchers express gratitude to all those involved in the study, including volunteers and staff.
- Funding support from various sources was instrumental in conducting the study and maintaining metabolomics facilities.
Title of paper: Oral Administration of Nicotinamide Mononucleotide Is Safe and Efficiently Increases Blood Nicotinamide Adenine Dinucleotide Levels in Healthy Subjects
Author(s): Okabe K, Yaku K, Uchida Y, Fukamizu Y, Sato T, Sakurai T, Tobe K, Nakagawa T.
Year published: 2022
Published in: Front Nutr
Original article can be found here.