Title: Nicotinamide Mononucleotide (NMN): A Potential Anti-Aging Intervention
Introduction: The availability of nicotinamide mononucleotide (NMN) decreases with age and certain diseases, making it an interesting compound to study for its potential anti-aging effects. NMN enhances NAD+ biosynthesis, improving various pathologies in mouse disease models. This article summarizes the findings of a 12-month administration of NMN in aging mice, highlighting its effects on age-associated physiological decline.
NMN and Anti-Aging Interventions
Efforts to develop effective, affordable anti-aging interventions have intensified. Promising compounds like NMN and nicotinamide riboside (NR) have shown therapeutic effects on metabolic complications and various diseases. Enhancing NAD+ biosynthesis with NMN is a potential therapeutic intervention against age-associated physiological decline.
The Benefits of NMN Administration
Long-term administration of NMN in mice ameliorated age-associated physiological decline, without causing any toxic effects. NMN administration had numerous positive effects, including suppressing age-associated body weight gain, enhancing energy metabolism and physical activity, improving insulin sensitivity and plasma lipid profile, and preserving eye function and other pathophysiologies.
Mechanisms of Action
NMN administration prevented age-associated gene expression changes, enhanced mitochondrial oxidative metabolism in skeletal muscle, and improved mitochondrial respiratory capacity. These effects demonstrate the potential of NAD+ intermediates as effective anti-aging interventions.
Pharmacokinetics and Dosage
NMN was quickly absorbed and converted to NAD+ in major metabolic tissues. Its optimal dosage varied depending on the physiological function being targeted. Skeletal muscle was found to be one of the most sensitive target tissues for the anti-aging effects of NMN.
The study was conducted on C57BL/6N male mice fed a regular chow diet. Body weights, food and water intake, blood samples, glucose and insulin tests, and other measurements were taken periodically. NMN was administered orally in drinking water at different doses. Statistical analyses were performed using various methods.
The study demonstrated that long-term administration of NMN mitigated age-associated physiological decline in mice. NMN had various positive effects on multiple aspects of health, and no significant toxic or deleterious effects were observed. The findings provide evidence for the potential of NMN as an effective anti-aging intervention in humans. Further research is needed to identify target organs and mechanisms of action for the effects observed.
Title of paper: Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice
Author(s): Mills KF, Yoshida S, Stein LR, Grozio A, Kubota S, Sasaki Y, Redpath P, Migaud ME, Apte RS, Uchida K, Yoshino J, Imai SI.
Year published: 2016
Published in: Cell Metab
Original article can be found here.