Improving lysosomal ferroptosis with NMN administration protects against heart failure

Improving lysosomal ferroptosis with NMN administration protects against heart failure

Title: Understanding the Benefits of NMN Supplementation for Heart Health

Introduction: NMN supplementation, also known as nicotinamide mononucleotide, has been found to have positive effects on heart health. This article summarizes a study that explores the impact of NMN supplementation on lysosome-mediated ferroptosis and the potential benefits for preventing chronic heart failure.

Ferroptosis and Cell Death

Ferroptosis is a specific form of cell death characterized by the accumulation of iron and lipid peroxidation. It plays a role in several diseases, including heart failure.

Role of NMN in Improving Autophagy

Autophagy is an essential cellular process responsible for removing damaged components and promoting cellular health. NMN supplementation has been shown to improve autophagy, potentially reducing the risk of heart failure.

NMN Supplementation and Lifespan Extension

In mice with mitochondrial translation deficiency, NMN supplementation has been found to prolong lifespan. Mitochondrial translation deficiency refers to impaired protein synthesis within the mitochondria, the cell's powerhouses.

Mitochondrial Translation Defects and Heart Disease

Mitochondrial disorders are associated with various cardiac diseases. Knockout of the mitochondrial translation factor p32 can lead to heart failure from dilated cardiomyopathy.

Impact of NMN on NAD+ Levels and Lysosomal Function

Mitochondrial translation defects lead to mitochondrial dysfunction and decreased NAD+ levels. Decreased NAD+ levels result in impaired lysosomal acidification and autophagy. However, NMN administration can compensate for decreased NAD+ levels and improve lysosomal function, leading to improved autophagy.

NMN Supplementation and Heart Failure

NMN administration has been found to reduce heart failure and extend lifespan in mice with p32 knockout. It improves lysosomal function and prevents ferroptosis-induced heart failure.

Mitochondrial Interaction with Other Organelles and Cellular Homeostasis

Mitochondria play a crucial role in cellular energy production and interact with other organelles. Membrane contact sites between mitochondria and lysosomes are important for cellular homeostasis.

NMN and Organelle Communication

Dysfunction of mitochondria and lysosomes can lead to various pathological conditions. NAD+ levels are crucial for organelle communication and metabolic processes. NMN administration increases NAD+ levels and improves lysosomal function, contributing to improved cardiac function.

NMN Supplementation Study Results

The administration of NMN in p32 knockout mice resulted in improved cardiac function, reduced fibrosis, and restored NAD+ levels. Additionally, NMN administration improved lysosomal and autophagic function, reduced ferroptosis, and increased lifespan.


NMN supplementation shows promising benefits for heart health by enhancing lysosomal function and reducing ferroptosis-induced heart failure. Further studies are needed to explore the potential use of NMN in lysosome-related diseases associated with aging.

Note: The article also includes sections on experimental procedures, data availability, and contact information for further inquiries. These sections provide additional details on the study methodology and resources used.

Title of paper: Improving lysosomal ferroptosis with NMN administration protects against heart failure

Author(s): Yagi M, Do Y, Hirai H, Miki K, Toshima T, Fukahori Y, Setoyama D, Abe C, Nabeshima YI, Kang D, Uchiumi T.

Year published: 2023

Published in: Life Sci Alliance

Original article can be found here.

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