Article Summary:
Title: NMN Intake in the Afternoon Improves Physical Performance and Reduces Drowsiness in Older Adults: A Randomized Controlled Trial
Introduction:
- Aging leads to deterioration of human tissues and organs, as well as cell senescence and oxidative damage.
- Geriatric syndromes, such as sarcopenia and frailty, can result from muscle and physical decline.
- Fatigue, a common symptom among the elderly, is associated with dullness, depression, cognitive dysfunction, and sleep disturbances.
- Effective interventions are necessary to improve physical activity, fatigue, and sleep quality in older adults.
Nicotinamide Mononucleotide (NMN) and its Effects:
- NMN is a precursor of nicotinamide adenine dinucleotide (NAD+) and plays a critical role in maintaining a healthy metabolism.
- NMN intake in mice has shown positive effects on weight, energy metabolism, insulin sensitivity, and eye function.
- Limited human clinical trials have shown positive effects of NMN intake on sleep quality, fatigue, and physical performance in older adults.
Study Design and Sample:
- The study was a randomized, double-blind, placebo-controlled parallel-group study.
- 108 older adults (≥65 years) residing in Tsukuba City, Japan, were divided into four groups: NMN_AM, NMN_PM, Placebo_AM, and Placebo_PM.
- Participants took NMN or placebo once a day for 12 weeks.
Results:
- Significant interactions were observed between 5-times sit-to-stand (5-STS) and drowsiness.
- After the intervention, all groups showed significant improvement in 5-STS and drowsiness.
- NMN_PM group showed the largest effect size for 5-STS and drowsiness.
- NMN intake in the afternoon effectively improved lower limb function and reduced drowsiness in older adults.
Conclusion:
- NMN supplementation in the afternoon may prevent loss of physical performance and improve fatigue in older adults.
- Further human clinical studies are needed to clarify the effectiveness and safety of NMN supplementation for anti-aging purposes.
Acknowledgements:
- The authors acknowledge the participants for their cooperation in the study and their contribution to the research.
- The study would not have been possible without the participants' involvement.
Author Information:
- The authors responsible for the study are M.K., T.S. (Toshiya Sato), T.S. (Takanobu Sakurai), Y.F., and T.O.
- M.K. was responsible for data curation, formal analysis, visualization, and writing the original draft.
Funding and Ethics:
- The study was funded by Mitsubishi Corporation Life Sciences Ltd.
- The study received ethical approval from the University of Tsukuba and followed the guidelines of the Declaration of Helsinki.
- Informed consent was obtained from all participants.
Data Availability and Conflicts of Interest:
- All data generated or analyzed during the study are included in the published article.
- The authors affirm that they have no conflicts of interest.
Publisher Disclaimer:
The publisher, MDPI, does not take any position on jurisdictional claims in published maps and remains neutral with regards to institutional affiliations.
Title of paper: Effect of 12-Week Intake of Nicotinamide Mononucleotide on Sleep Quality, Fatigue, and Physical Performance in Older Japanese Adults: A Randomized, Double-Blind Placebo-Controlled Study
Author(s): Kim M, Seol J, Sato T, Fukamizu Y, Sakurai T, Okura T.
Year published: 2022
Published in: Nutrients
Original article can be found here.
