Dr. Andrew Huberman and NMN and Other Supplements

Dr. Andrew Huberman and NMN and Other Supplements

Dr. Andrew Huberman, a distinguished neuroscientist and professor at Stanford University and famous for his podcast Huberman Lab, has become increasingly recognized not only for his contributions to the field of neuroscience but also for his insights into health and longevity practices, especially concerning the use of supplements. His approach to supplements is both scientific and personal, as he often engages in self-experimentation and shares his experiences with a wider audience, notably through his popular podcast, Huberman Lab. Among the various supplements he discusses, NMN (Nicotinamide Mononucleotide) stands out due to its potential benefits in enhancing health and longevity.

Understanding NMN and its Role in Health

NMN, a derivative of vitamin B3 (niacin), plays a critical role in the production of nicotinamide adenine dinucleotide (NAD+), a coenzyme essential for a myriad of metabolic processes. As the body ages, NAD+ levels naturally decline, leading to a decrease in cellular energy and increased susceptibility to age-related diseases. NMN supplementation is thought to counteract these effects by boosting NAD+ levels, potentially offering a range of health benefits, from improved energy metabolism to delayed aging.

Dr. Huberman's Personal Use of NMN

Usage and Dosage

Dr. Huberman takes NMN as part of his daily supplement routine, opting for a substantial dose of 1 to 2 grams. This dosage is significant, as it exceeds the amounts typically seen in over-the-counter supplements. His choice of this higher dose aligns with his aim to effectively increase his NAD+ levels rather than merely to supplement his diet with a nominal amount of NMN.

Subjective Effects

One of the key aspects of Dr. Huberman's approach to supplements is his emphasis on subjective experiences. He has reported notable effects from his NMN supplementation, including a perceptible increase in energy levels and an improved rate of recovery from physical workouts. Moreover, he has observed accelerated growth in his hair and nails, a change he attributes to his NMN intake.

Choice of Brand

In terms of brand preference, Dr. Huberman has publicly endorsed Renue by Science, a company known for its NMN supplements. His choice is based not only on the quality of the product but also on its form – he opts for a sublingual powder. This preference for the sublingual route over capsules or tablets is informed by his belief, shared by other experts like Dr. Peter Attia, that sublingual administration leads to better absorption of NMN into the body.

Sublingual Administration

The method of administration is a crucial factor in supplement efficacy. By choosing to take NMN sublingually, Dr. Huberman aligns with the perspective that this method allows for more direct absorption into the bloodstream, bypassing the digestive system where some of the compound might be lost or broken down. This approach is indicative of his meticulous attention to the details of supplement administration and its impact on effectiveness.

Broader Context of NMN Use and Research

The interest in NMN and related compounds like NR (Nicotinamide Riboside) extends beyond individual experiences and has been the subject of scientific research. Studies have explored the potential of these compounds to improve various aspects of health, including cardiovascular function, neuroprotection, and even lifespan extension in animal models. This research, while still in its early stages, has sparked a growing interest in the role of NAD+ metabolism in aging and disease.

Huberman's Perspective on Supplements and Longevity

Dr. Huberman’s approach to using supplements like NMN is grounded in a broader philosophy of health and longevity. He emphasizes the importance of a holistic approach to wellness, which includes regular exercise, a balanced diet, and proper sleep. Supplements, in his view, are not standalone solutions but part of a larger lifestyle strategy aimed at maintaining optimal health and vitality, especially as one ages.

His discussions often highlight the need for individualized approaches to supplementation, recognizing that what works for one person may not be suitable for another. This personalized approach is particularly relevant given the variability in how individuals respond to supplements, depending on factors like genetics, lifestyle, and existing health conditions.


Other Supplements Used by Dr. Andrew Huberman

In addition to NMN, Dr. Andrew Huberman incorporates a range of other supplements into his daily routine, each chosen for its specific health benefits:

Grapeseed Extract

  • Benefits: Grapeseed extract is known for its high content of resveratrol, a compound lauded for its potential cardiovascular benefits.
  • Usage: Huberman takes this primarily for its impact on vascular health, though it’s not in his list of top supplements.

NR (Nicotinamide Riboside)

  • Role: Like NMN, NR is a precursor to NAD+, vital for cellular energy and metabolism.
  • Synergy with NMN: Huberman takes NR alongside NMN to boost his NAD+ levels, reflecting a comprehensive approach to leveraging the benefits of NAD+ precursors.


  • Cognitive Enhancement: This supplement is used by Huberman to improve cognitive function and motivation, particularly before demanding mental tasks or intense workouts.
  • Frequency of Use: He takes Alpha-GPC about four times weekly, especially when needing to focus intensely.


  • Focus and Attention: Used occasionally, L-Tyrosine is a precursor to dopamine, which plays a crucial role in mood regulation and cognitive function.
  • Caveat: Huberman notes a potential crash after its use and recommends careful timing, such as avoiding use when already sleep-deprived.

Phenylethylamine (PEA)

  • Mood and Attention: PEA is known for its effects on improving mood and attention, acting as a natural stimulant.
  • Usage Pattern: Huberman uses PEA occasionally as a work aid, often in conjunction with Alpha-GPC for a more pronounced effect.

Testosterone Support

  • Supplements: His regimen includes Tongkat Ali and Fadogia Agrestis, known for their potential to support healthy testosterone levels.
  • Holistic Approach: Huberman emphasizes the importance of lifestyle factors like sleep, diet, and exercise in conjunction with these supplements.

Dr. Huberman's Approach to Supplements

Holistic Health

  • Comprehensive Wellness: Huberman advocates for a balanced approach, emphasizing the role of sleep, diet, exercise, and stress management as foundational to health.
  • Supplements as Adjuncts: He views supplements as additions to, not replacements for, these fundamental health practices.

Personal Experimentation

  • Self-Testing: Huberman often engages in personal experimentation with supplements, sharing his subjective experiences and outcomes.
  • Informed Choices: His approach is grounded in both scientific understanding and personal observation, allowing for a nuanced perspective on supplement use.

Transparency and Independence

  • No Financial Ties: He makes it clear that he has no financial relationships with any NMN or NR manufacturing companies.
  • Objective Advice: This independence enables him to provide advice and insights that are based on personal experience and scientific knowledge, rather than commercial interests.

The Larger Context of Huberman's Supplement Use

Dr. Huberman's use of these supplements, especially NMN, ties into his broader interest in maintaining mental and physical energy as he ages. His approach underscores the importance of individual research and consultation with healthcare providers before starting any supplement regimen. This cautious and informed perspective is crucial given the variability in individual responses to supplements and the evolving nature of scientific research in this area.

Huberman's insights into supplement use, combined with his expertise in neuroscience, provide a valuable resource for those interested in optimizing their health and wellbeing. His holistic approach to health, emphasis on personal experimentation, and commitment to transparency offer a model for how individuals can approach supplement use in an informed and balanced way.

In summary, Dr. Andrew Huberman's approach to supplement use is characterized by a thoughtful combination of scientific understanding, personal experience, and a holistic view of health. His regimen, which includes a variety of supplements like NMN, Grapeseed Extract, Alpha-GPC, L-Tyrosine, PEA, and testosterone-supporting supplements, is underpinned by a philosophy that emphasizes the importance of a balanced lifestyle and personalized health strategies. His transparency and independence in discussing these supplements add credibility to his insights, making him a respected figure in the conversation around health optimization and longevity.





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