NMN vs Vitamin B12

NMN vs Vitamin B12

In the bustling world of health and nutrition, selecting the right dietary supplements can be a daunting, if not outright perplexing task. Furthermore, the more we venture into this intricate terrain, the deeper the labyrinth seems to grow. Everyday scientific research uncovers new substances, unveiling their indispensable roles in maintaining our health and vigor. Today, we find ourselves navigating through a similar labyrinth as we contemplate two notable partners in catapulting optimal health: Nicotinamide Mononucleotide (NMN) and Vitamin B12. These two players may seem akin at the initial glance, but a closer inspection reveals their distinctive features, making them shine in their individual arenas.

Nicotinamide Mononucleotide (NMN)

Nicotinamide Mononucleotide, abbreviated as NMN, is a relatively new protagonist in this spacious realm of nutrients, still in the initial stages of its exploration. NMN is a precursor to Nicotinamide Adenine Dinucleotide (NAD+), a coenzyme found in all living cells. NAD+ plays significant roles in various biological processes, particularly in energy metabolism and DNA repair. An elevation in NAD+ levels fueled by NMN intake is thought to mitigate age-related degradation, boost energy, improve cognitive function, enhance physical performance, and even confer increased lifespan.

Vitamin B12

Contrarily, Vitamin B12, or Cobalamin, is a respected veteran in the world of essential vitamins. Essential for nerve tissue health, brain function, and the production of red blood cells, it also takes part in DNA synthesis and metabolism[1]. Natural sources include animal-derived foods such as meat, poultry, fish, eggs, and dairy. Additionally, vegetarians and vegans can opt for fortified foods or supplements[2].

One glaring difference between NMN and B12 is the rarity of genuine deficiencies. Compared to Vitamin B12, deficiencies of NMN are not known since the body can synthesize NMN naturally using the vitamin B3 (niacin). On the state of Vitamin B12, however, deficiency can result from various factors, including the inadequate intake of animal-derived foods, impaired absorption due to alcoholism or specific conditions involving the stomach and intestines[3]. These range from minor symptoms, like fatigue and constipation, to severe neurological problems and hematological disorders[4].

Research on NMN is earnest, yet nascent, with the bulk of studies focusing on animal models. This is a stark contrast to the suite of clinical studies and practical experiences underpinning the benefits of Vitamin B12. Current evidence promises that NMN therapy boosts NAD+ levels in humans, just as it does in mice. It is likelier to delay multiple aspects of physiological decline, thereby enhancing the quality of life rather than extending longevity per se, as in mice[5]. In actuality, research is sufficiently encouraging to warrant clinical trials. The first human study on this front was performed in Japan probing the safety of oral NMN[6].

Vitamin B12, alternatively, is armed with extensive research validating its essentiality for human health. It is vitally involved in maintaining the health of your body's nerve and blood cells and even affects DNA synthesis and function[1]. Moreover, it works clueless with other B vitamins, like B9, to regulate levels of the amino acid homocysteine to promote heart health[7].

While there are claims about the cooperative performance of these two nutrients, no scientific evidence supports switching one for the other. NMN and Vitamin B12 cater to multiple, yet unique biological functions. Replacing one may jeopardize those distinct roles that the other does not fulfill.

Purchasing these supplements is contingent on reliable sources given the bulging black market for health supplements. Reputable online retailers, such as Amazon and iHerb, provide accessibility to a broad range of NMN and B12 supplements.

The cost could factor into individuals' decisions in their acquisition. NMN currently commands a premium price, attributed to its novelty and the gradually escalating scientific hype. By contrast, Vitamin B12 supplements are significantly more affordable, which reflects its ubiquity and widespread manufacture.

As our traverse through the course of the minutiae on NMN and Vitamin B12 draws to a close, it's essential to reaffirm that while both supplements convey notable benefits, they are not interchangeable. They hold unique, tailored roles in our bodies, placing them both as invaluable contributors to our health, performance, and well-being. However, before incorporating any supplement into your regimen, it's advisable to consult a healthcare professional for tailored advice based on your personal needs and risk factors.

In conclusion, the science of nutrition is a complex pursuit, but it is also a fascinating journey leading us to understand our bodies better and challenge the bounds of human potential.


  1. https://ods.od.nih.gov/factsheets/VitaminB12-Consumer/
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042564/
  3. https://medlineplus.gov/ency/article/002403.htm
  4. https://www.nhs.uk/conditions/vitamin-b12-or-folate-deficiency-anaemia/symptoms/
  5. https://www.cell.com/cell-metabolism/comments/S1550-4131(21)00065-6
  6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359187/
  7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612599/
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